Dissolution study and method validation of alprazolam by high performance liquid chromatography method in pharmaceutical dosage form

Dissolution study was carried for alprazolam solubility study, conditions selected for paddle was 100 rpm, using 500 ml potassium dihydrogen phosphate of pH 6.8 at temperature as 37°C. These conditions are useful for % release of alprazolam was achieved on symmetyshield RP8 (150 x 3.9 mm i.d, 5 μ.) column was most suitable for dissolution study with mixture of (60:40 % v/v) of buffer and acetonitrile as mobile phase. A and to tri-ethylamine was used to adjust the pH 3.0 of buffer. The diluent. The detector wavelength was set at 225 nm. performed as per ICH guidelines. The linearity was found between 50 RSD of precision was 0.66%.